Can I read Fluorine-19 NMR studies of tumor-bearing rats treated with difluoromethylornithine on EtoBox?
Fluorine-19 NMR studies of tumor-bearing rats treated with difluoromethylornithine by Andrew Joseph; Clark Davenport; Lester Kwock; C. Tyler Burt; Robert E. London is a Medicine article available to read on EtoBox.
What is Fluorine-19 NMR studies of tumor-bearing rats treated with difluoromethylornithine about?
Copenhagen rats with implanted metastatic prostate carcinomas have been treated with the drug alpha-difluoromethylornithine (DFMO), an inhibitor of the enzyme ornithine decarboxylase. In vivo and in vitro 19F NMR observations were then carried out on a variety of organs and tissues. The distribution of the drug strongly favored tumor over surrounding muscle. DFMO, which gives a spectrum similar to that of the pH indicator difluoromethylalanine, has potential for determination of in vivo pH. However, in contrast to the alanine analog, DFMO exhibits a considerably smaller shift dependence in response to pH changes.
Who reads Fluorine-19 NMR studies of tumor-bearing rats treated with difluoromethylornithine?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Andrew Joseph; Clark Davenport; Lester Kwock; C. Tyler Burt; Robert E. London
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)
- Published
- 1987
- Language
- EN
- Field
- Medicine (Health Sciences)