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Comparison of methimazole and propylthiouracil in the management of children and adolescents with Graves’ disease: efficacy and adverse reactions during initial treatment and long-term outcome by Hirokazu Sato; Masanori Minagawa; Nozomu Sasaki; Shigetaka Sugihara; Itsuro Kazukawa; Kanshi Minamitani; Kunio Wataki; Susumu Konda; Hiroaki Inomata; Kazunori Sanayama; Yoichi Kohno is a Medicine article available to read on EtoBox.

What is Comparison of methimazole and propylthiouracil in the management of children and adolescents with Graves’ disease: efficacy and adverse reactions during initial treatment and long-term outcome about?

## Objective: The aim of this study was to compare the efficacy and adverse reactions during initial treatment and longterm outcome between children and adolescents with Graves ' disease (GD) treated with propylthiouracil (PTU) and those treated with methimazole (MMI). Design, setting and participants: Retrospective and collaborative study. Children and adolescents with GD were divided into group M (MMI: n = 64) and group P (PTU: n = 69) and into four subgroups by initial dose: group M1 ( < 0.75 mg/kg of MMI, n = 34), group M2 ( ≥ 0.75 mg/kg, n = 30), group P1 ( < 7.5 mg/kg of PTU, n = 24) and group P2 ( ≥ 7.5 mg/kg, n = 45).

Who reads Comparison of methimazole and propylthiouracil in the management of children and adolescents with Graves’ disease: efficacy and adverse reactions during initial treatment and long-term outcome?

Author

Hirokazu Sato; Masanori Minagawa; Nozomu Sasaki; Shigetaka Sugihara; Itsuro Kazukawa; Kanshi Minamitani; Kunio Wataki; Susumu Konda; Hiroaki Inomata; Kazunori Sanayama; Yoichi Kohno

Publisher

Walter de Gruyter GmbH

Published

2011

Language

EN

Field

Medicine (Health Sciences)