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What is Opioid Tolerance: Allostatic Mechanisms Explained about?

The document reviews mechanisms of opioid tolerance, emphasizing cellular allostasis and the regulation of opioid receptor signalosomes. It introduces the concept of pass-forward allostasis, where opioid-induced changes affect downstream circuitry, impacting all brain cells in opioid-dependent states. The authors highlight the roles of neurons and microglia in the cumulative allostatic processes that contribute to analgesic and hedonic tolerance to opioids.

Author

anjolaolajide54

Language

EN