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This document describes a potentiometric titration method for determining the concentrations of gatifloxacin (GTFX) and ciprofloxacin (CPFX) in pure drugs and pharmaceutical formulations. The method is based on the oxidation reaction of GTFX and CPFX with cerium(IV) in acid media. The reactions were found to be quantitative with a 1:4 stoichiometry of drug to Ce4+ in 0.25M HNO3. The potentiometric titration method can determine GTFX and CPFX concentrations over specific ranges with relative standard deviati

Author

ErvinaOctaviani

Language

EN