Can I read Mechanisms of Heparin Transport Through Expanded Poly(tetrafluoroethylene) Vascular Grafts on EtoBox?

Mechanisms of Heparin Transport Through Expanded Poly(tetrafluoroethylene) Vascular Grafts by Insup Noh; Mark A. Lovich; Elazer R. Edelman is a Medicine article available to read on EtoBox.

What is Mechanisms of Heparin Transport Through Expanded Poly(tetrafluoroethylene) Vascular Grafts about?

Thrombosis and neointimal hyperplasia limit the utility of small-caliber artificial vascular grafts. Surface modifications and adjunctive pharmacological therapy might mediate these complications. We examined the mechanisms by which a model vasoactive compound, heparin, transverses porous graft materials and how material modifications alters this drug's transport. The effective permeance of [ 3 H]heparin was measured after application of a uniform concentration of drug to either the internal or external surface of the graft and in the presence or absence of pressure-driven physiologic hydraulic flows. Transgraft permeance was equivalent to those observed in normal arteries and, while enhanced by convection, was mediated in major part by diffusion. Peclet numbers under the various conditions examined ranged from 0.05 to 1.2, indicating that diffusive forces were equal to or exceeded convective forces in governing transmural heparin motion. Heparin traversed the graft even when applied from the outer perivascular surface, against adverse hydraulic flows. Modifications of the grafts that included a yarn barrier of spun poly(tetrafluoroethylene) or chemical modification of surface tens

Who reads Mechanisms of Heparin Transport Through Expanded Poly(tetrafluoroethylene) Vascular Grafts?

Author

Insup Noh; Mark A. Lovich; Elazer R. Edelman

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)

Published

2000

Language

EN

Field

Medicine (Health Sciences)