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Multiple types of mRNA‐cytoskeleton interactions by G. Zambetti; E. G. Fey; S. Penman; J. Stein; G. Stein is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Multiple types of mRNA‐cytoskeleton interactions about?

Nearly all actively translated mRNAs are associated with the cytoskeleton in HeLa cells and the nature of this association is poorly understood. To gain insight into this association, we have examined and compared the cytoskeleton-mRNA interactions of a signal peptide-histone fusion mRNA (membrane-bound polysomal mRNA) to those of endogenous histone mRNA (nonmembrane-bound polysomal mRNA). We report here the detection of a cytoskeleton attachment site within the signal peptide-histone fusion mRNP/mRNA nucleotide sequence that is not present in wild-type histone mRNA or in HLA-B7 and chorionic gonadotropin-a membrane-bound polysomal mRNAs. These results support the possibility that there are multiple mechanisms for the attachment of specific classes of mRNAs to the cytoskeleton. ## mRNA-Cytoskeleton Interactions JCB187 G.Z. is a recipient of a Sigma Chi Grant-in-Aid of Research Award. We thank Tim Morns, Dave Collart, and Andre van Wijnen for their helpful discussions and Marie Giorgio for her assistance with the photography.

Who reads Multiple types of mRNA‐cytoskeleton interactions?

Author

G. Zambetti; E. G. Fey; S. Penman; J. Stein; G. Stein

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)

Published

1990

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)