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Hodgkin's disease presenting as a solitary bone tumor: A report of four cases and review of the literature by Metin Ozdemirli; Henry J. Mankin; Alan C. Aisenberg; Nancy L. Harris is a Medicine article available to read on EtoBox.

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## BACKGROUND. Hodgkin's disease (HD) rarely presents as a solitary bone tumor. Fewer than 20 such cases have been reported in the English literature; many of these were reported prior to the development of immunohistologic markers for HD and T-and B-cell lymphomas. In this report, we describe four cases of HD that presented as a localized solitary mass in bone; the diagnosis was confirmed by immunohistochemical studies in all cases. METHODS. The biopsy specinlens of four cases identified in our files were studied by conventional histopathology and immunohistochemistry. Clinical data and follow-up information were obtained for all patients. RESULTS. Three cases presented as a localized, solitary mass in the ilium and one case in the vertebra (T12). Three patients were female and one male. The average age was 43 years. Three of the patients presented with lower back pain without constitutional symptoms. All had solitary osteoblastic lesions. All four cases were diagnostic problems, and the diagnosis was confirmed in each case only after finding lymph node involvement. Bone biopsies showed fibrosis and a mixed inflammatory infiltrate with rare atypical cells. All four patients were s

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Author

Metin Ozdemirli; Henry J. Mankin; Alan C. Aisenberg; Nancy L. Harris

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1996

Language

EN

Field

Medicine (Health Sciences)