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Identification of colon‐tumor‐associated antigens by T‐cell lines derived from tumor‐infiltrating lymphocytes and peripheral‐blood lymphocytes from patients immunized with an autologous tumor‐cell/bacillus calmette‐Guérin vaccine by Janet H. Ransom; Barbara A. Pelle; Henk Hubers; Linette M. Keynton; Michael G. Hanna; Nicholas Pomato is a Medicine article available to read on EtoBox.

What is Identification of colon‐tumor‐associated antigens by T‐cell lines derived from tumor‐infiltrating lymphocytes and peripheral‐blood lymphocytes from patients immunized with an autologous tumor‐cell/bacillus calmette‐Guérin vaccine about?

## Abstract Tumor immunity developing as a response to an autologous colon‐tumor/bacillus Calmette‐Guerin (BCG) vaccine appears to be associated with induction of CD4 helper T cells, implied by the observation that vaccine efficacy is associated with major histocompatibility complex class‐ll molecule expression on the vaccine tumor cells. Therefore, in an attempt to identify colon‐tumor‐associated antigens responsible for conferring immunity, we examined and compared the proliferative responses of peripheral‐blood lymphocytes (PBL) from patients immunized with the autologous tumor/BCG vaccine to T‐cell lines cloned expanded from colon‐tumor‐infiltrating lymphocytes to 5 antigens isolated on the basis of their reactivity by colon‐tumor‐reactive human monoclonal antibodies. Enzymatically dissociated colon tumors provided a source for establishment of cloned T‐cell lines, tumor cell lines propagated __in vitro__ or __in vivo__ as nude‐mouse xenografts and EBV‐transformed B‐cell lines used as antigen‐presenting cells. Of 104 different T‐cell lines tested, only 3 proliferated in response to CTAA 28A32‐46K, and I to the CTAA28A32‐32K antigen. In contrast, PBL from 64% of patients immuniz

Who reads Identification of colon‐tumor‐associated antigens by T‐cell lines derived from tumor‐infiltrating lymphocytes and peripheral‐blood lymphocytes from patients immunized with an autologous tumor‐cell/bacillus calmette‐Guérin vaccine?

Author

Janet H. Ransom; Barbara A. Pelle; Henk Hubers; Linette M. Keynton; Michael G. Hanna; Nicholas Pomato

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1993

Language

EN

Field

Medicine (Health Sciences)