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3D-QSAR Design of Bcr-Abl Inhibitors by Jaime Mella is a document available to read on EtoBox.
This study focuses on the design and synthesis of new purine derivatives as Bcr-Abl inhibitors for chronic myeloid leukemia (CML), particularly targeting imatinib-resistant mutations like T315I. Utilizing 3D-QSAR models, seven new compounds were synthesized, with two showing superior inhibition activity compared to imatinib. The research highlights the potential of these new inhibitors and in silico modeling techniques in developing effective treatments for CML patients resistant to current therapies.
- Author
- Jaime Mella
- Language
- EN