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Predictors of sustained response to alpha interferon therapy in chronic hepatitis C by Manuela G Neuman; Jean-Pierre Benhamou; Michelle Martinot; Nathalie Boyer; Neil H Shear; Izabella Malkiewicz; Gady G Katz; Ashima Suneja; Steve Singh; Patrick Marcellin is a Medicine article available to read on EtoBox.

What is Predictors of sustained response to alpha interferon therapy in chronic hepatitis C about?

Objectives: To utilize cytokine levels to predict sustained response (SR) to alpha interferon (IFN ␣) therapy in chronic hepatitis C patients, and to determine the relationship between serum tumor necrosis factor ␣ (TNF ␣), interleukin (IL) IL 6, IL 8, IL 12, transforming growth factor beta (TGF ␤ 1) and the degree of liver damage as reflected by traditional markers. Design and methods: Serum cytokine levels were assessed using ELISA in 18 patients included in a controlled clinical trial of IFN ␣. Results: Of the 18 patients, 27% were sustained responders (SR), 27% were response and relapse responders (RR), and 46% were non-responders (NR). Multivariate analysis showed that a low serum TNF ␣ level and high serum IL 8 levels were independent factors associated with SR to IFN ␣ therapy. Serum TNF ␣ level highly correlated with viral load and genotype predictive values (p Ͻ 0.001). Therapy lowered the IL 6 and IL 12 profile. TGF ␤ 1 levels in serum are positively correlated with fibrinogenesis. Conclusions: IFN ␣ therapy modulates immune response to hepatits C virus, contributing to sustained response.

Who reads Predictors of sustained response to alpha interferon therapy in chronic hepatitis C?

Author

Manuela G Neuman; Jean-Pierre Benhamou; Michelle Martinot; Nathalie Boyer; Neil H Shear; Izabella Malkiewicz; Gady G Katz; Ashima Suneja; Steve Singh; Patrick Marcellin

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-9120)

Published

1999

Language

EN

Field

Medicine (Health Sciences)