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MicroRNAs as the critical regulators of Doxorubicin resistance in breast tumor cells by Zangouei, Amir Sadra (author);Alimardani, Maliheh (author);Moghbeli, Meysam (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is MicroRNAs as the critical regulators of Doxorubicin resistance in breast tumor cells about?

## Background Chemotherapy is one of the most common treatment options for breast cancer (BC) patients. However, about half of the BC patients are chemotherapeutic resistant. Doxorubicin (DOX) is considered as one of the first line drugs in the treatment of BC patients whose function is negatively affected by multi drug resistance. Due to the severe side effects of DOX, it is very important to diagnose the DOX resistant BC patients. Therefore, assessment of molecular mechanisms involved in DOX resistance can improve the clinical outcomes in BC patients by introducing the novel therapeutic and diagnostic molecular markers. MicroRNAs (miRNAs) as members of the non-coding RNAs family have pivotal roles in various cellular processes including cell proliferation and apoptosis. Therefore, aberrant miRNAs functions and expressions can be associated with tumor progression, metastasis, and drug resistance. Moreover, due to miRNAs stability in body fluids, they can be considered as non-invasive diagnostic markers for the DOX response in BC patients. ## Main body In the present review, we have summarized all of the miRNAs that have been reported to be associated with DOX resistance in BC for

Who reads MicroRNAs as the critical regulators of Doxorubicin resistance in breast tumor cells?

Author

Zangouei, Amir Sadra (author);Alimardani, Maliheh (author);Moghbeli, Meysam (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)