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Proinflammatory Role of Amphiregulin, an Epidermal Growth Factor Family Member Whose Expression Is Augmented in Rheumatoid Arthritis Patients by Shoji Yamane; Satoru Ishida; Yukie Hanamoto; Ken-ichi Kumagai; Riako Masuda; Konagi Tanaka; Noriyuki Shiobara; Noriko Yamane; Toshihito Mori; Takuo Juji; Naoshi Fukui; Tsunetoshi Itoh; Takahiro Ochi; Ryuji Suzuki is a Medicine article available to read on EtoBox.

What is Proinflammatory Role of Amphiregulin, an Epidermal Growth Factor Family Member Whose Expression Is Augmented in Rheumatoid Arthritis Patients about?

## Background The epidermal growth factor (EGF) and EGF receptor (EGFR) families play important roles in the hyperplastic growth of several tissues as well as tumor growth. Since synovial hyperplasia in rheumatoid arthritis (RA) resembles a tumor, involvement of the EGF/EGFR families in RA pathology has been implied. Although several reports have suggested that ErbB2 is the most important member of the EGFR family for the synovitis in RA, it remains unclear which members of the EGF family are involved. To clarify the EGF-like growth factors involved in the pathology of RA, we investigated the expression levels of seven major EGF-like growth factors in RA patients compared with those in osteoarthritis (OA) patients and healthy control subjects. ## Methods The expression levels of seven EGF-like growth factors and four EGFR-like receptors were measured in mononuclear cells isolated from bone marrow and venous blood, as well as in synovial tissues, using quantitative RT-PCR. Further evidence of gene expression was obtained by ELISAs. The proinflammatory roles were assessed by the growth-promoting and cytokine-inducing effects of the corresponding recombinant proteins on cultured fibro

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Author

Shoji Yamane; Satoru Ishida; Yukie Hanamoto; Ken-ichi Kumagai; Riako Masuda; Konagi Tanaka; Noriyuki Shiobara; Noriko Yamane; Toshihito Mori; Takuo Juji; Naoshi Fukui; Tsunetoshi Itoh; Takahiro Ochi; Ryuji Suzuki

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2004-; Springer Science and Business Media LLC (ISSN 1476-9255)

Published

2008

Language

EN

Field

Medicine (Life Sciences)