Can I read The immunoregulatory effects of NK cells: the role of TGF-β and implications for autoimmunity on EtoBox?

The immunoregulatory effects of NK cells: the role of TGF-β and implications for autoimmunity by David A. Horwitz; J.Dixon Gray; Kazuo Ohtsuka; Makoto Hirokawa; Tetsu Takahashi is a Immunology and Microbiology article available to read on EtoBox.

What is The immunoregulatory effects of NK cells: the role of TGF-β and implications for autoimmunity about?

GCD4\* + CDEI' WCW4' + CDB' ' cells, including macrophagw and IymphwyteP, have the capacity b prodwe TGF-P, and virtually a,, cell hjpes express hiahaffinihr ,e&ive,y activates CDS-T rd,s ,a ~mliferate", and a"g",c",r the maturatio" of T tells ,mm naive LO activated or memos crw. The regulabry effects of TGF-,, on T-cell cyrokiae prcdtiio" is contnr versia,. hme gm"ps have rqxvtpd that TGF-6 fadlitates ,he conditioning of CD4\* ce,,s to pmducr IL-2 and lFNq (Ref. 341. Mhen, however, "port that TGF-B has ,he oppasite e'fect and pmmotw h"mora, immuni(y by upregulating 1L-4, n-5 and IL-10 pmdvc ,ialP. The ultimate effrx, "f TGF-,3 is presumably \*e,cml,"cd by ,he inferacting ce,,s and cytokincs in the immediate milieu. NOVEMBER Suppressive \* cytokmes Active TGF-8 .-\_ NK cell IMMUNOLOGY TODAY systems is IgA antibody production or nonresponsiveness. It is Thus, in addition to their c) totoxic activities as a first line of de-likely that NK ceils have an important role in promoting this negafense in combating infectious agents, NK cells may have an equally tive response by their ability to provide TGF-p. Without stimulation, NK cells in peripheral blood produce nanomolar amounts of thi

Who reads The immunoregulatory effects of NK cells: the role of TGF-β and implications for autoimmunity?

Author

David A. Horwitz; J.Dixon Gray; Kazuo Ohtsuka; Makoto Hirokawa; Tetsu Takahashi

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0167-5699)

Published

1997

Language

EN

Field

Immunology and Microbiology (Life Sciences)