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Bone Turnover and Mineral Metabolism in Adult Patients with Hypophosphatasia Treated with Asfotase Alfa by L. Seefried; D. Rak; A. Petryk; F. Genest is a Medicine article available to read on EtoBox.

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## Summary There is limited understanding of how asfotase alfa affects mineral metabolism and bone turnover in adults with pediatric-onset hypophosphatasia. This study showed that adults with hypophosphatasia treated with asfotase alfa experienced significant changes in biochemical markers of bone and mineral metabolism, possibly reflecting enhanced bone remodeling of previously osteomalacic bone. ## Introduction Hypophosphatasia (HPP), due to a tissue nonspecific alkaline phosphatase (TNSALP) deficiency, can cause impaired bone mineralization and turnover. Although HPP may be treated with asfotase alfa, an enzyme replacement therapy, limited data are available on how treatment with asfotase alfa affects mineral metabolism and bone turnover in adults with HPP. ## Methods ALP substrates, bone turnover and mineral metabolism markers, and bone mineral density (BMD) data from EmPATHY, a single-center, observational study of adults (≥ 18 years) with pediatric-onset HPP treated with asfotase alfa (NCT03418389), were collected during routine clinical care and analyzed from baseline through 24 months of treatment. ## Results Data from 21 patients showed significantly increased ALP activity

Who reads Bone Turnover and Mineral Metabolism in Adult Patients with Hypophosphatasia Treated with Asfotase Alfa?

Author

L. Seefried; D. Rak; A. Petryk; F. Genest

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)