Opening book details…
Can I read RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells on EtoBox?
RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells by Nico Andreas; Maria Potthast; Anna-Lena Geiselhöringer; Garima Garg; Renske de Jong; Julia Riewaldt; Dennis Russkamp; Marc Riemann; Jean-Philippe Girard; Simon Blank; Karsten Kretschmer; Carsten Schmidt-Weber; Thomas Korn; Falk Weih; Caspar Ohnmacht is a Immunology and Microbiology article available to read on EtoBox.
What is RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells about?
Foxp3 regulatory T cells are well-known immune suppressor cells in various settings. In this study, we provide evidence that knockout of the gene in dendritic cells (DCs) of C57BL/6 mice results in a spontaneous and systemic accumulation of Foxp3 T regulatory T cells (Tregs) partially at the expense of microbiota-reactive Tregs. Deletion of does not fully recapitulate this phenotype, indicating that alternative NF-κB activation via the RelB/p52 complex is not solely responsible for Treg accumulation. Deletion of RelB in DCs further results in an impaired oral tolerance induction and a marked type 2 immune bias among accumulated Foxp3 Tregs reminiscent of a tissue Treg signature. Tissue Tregs were fully functional, expanded independently of IL-33, and led to an almost complete Treg-dependent protection from experimental autoimmune encephalomyelitis. Thus, we provide clear evidence that RelB-dependent pathways regulate the capacity of DCs to quantitatively and qualitatively impact on Treg biology and constitute an attractive target for treatment of autoimmune diseases but may come at risk for reduced immune tolerance in the intestinal tract.
Who reads RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Nico Andreas; Maria Potthast; Anna-Lena Geiselhöringer; Garima Garg; Renske de Jong; Julia Riewaldt; Dennis Russkamp; Marc Riemann; Jean-Philippe Girard; Simon Blank; Karsten Kretschmer; Carsten Schmidt-Weber; Thomas Korn; Falk Weih; Caspar Ohnmacht
- Publisher
- American Association of Immunologists; The American Association of Immunologists (ISSN 0022-1767)
- Published
- 2019
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)