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Association of intronic polymorphism rs3773364 A>G in synapsin‐2 gene with idiopathic epilepsy by Ram Lakhan; J. Kalita; U.K. Misra; Ritu Kumari; Balraj Mittal is a Neuroscience article available to read on EtoBox.

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## Abstract In epilepsy, there is a tendency towards recurrent unprovoked seizures. Seizures result due to the excessive electrical misfiring in the brain between neurons and disturbance in neurotransmitter release. Several gene products affect the behavior of these neurons by regulating neurotransmission via several mechanisms. One such gene, Synapsin‐2 (__SYN2)__, involved in synaptogenesis is also reported to regulate the neurotransmitter release. We hypothesized that __SYN2__ gene and its polymorphisms could affect the process of epileptogenesis and therapeutic response in humans. In this hospital‐based study, we enrolled 372 patients with epilepsy and 199 control subjects. We selected rs3773364 A>G polymorphism in __SYN2__ gene and analyzed its distribution in north Indian patients with epilepsy and control subjects. Genotyping was carried out by polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) method. According to the results obtained, __SYN2__ “AG” genotype frequency was significantly higher in patients with epilepsy versus control subjects in north Indian population (__P__ = 0.02, OR = 1.55, 95% CI = 1.06–2.26). After subclassification, we obser

Who reads Association of intronic polymorphism rs3773364 A>G in synapsin‐2 gene with idiopathic epilepsy?

Author

Ram Lakhan; J. Kalita; U.K. Misra; Ritu Kumari; Balraj Mittal

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)

Published

2009

Language

EN

Field

Neuroscience (Life Sciences)