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Can I read Neo-adjuvant chemo-radiation of rectal cancer with Volumetric Modulated Arc Therapy: summary of technical and dosimetric features and early clinical experience on EtoBox?
Neo-adjuvant chemo-radiation of rectal cancer with Volumetric Modulated Arc Therapy: summary of technical and dosimetric features and early clinical experience by Antonella Richetti; Antonella Fogliata; Alessandro Clivio; Giorgia Nicolini; Gianfranco Pesce; Emanuela Salati; Eugenio Vanetti; Luca Cozzi is a Medicine article available to read on EtoBox.
What is Neo-adjuvant chemo-radiation of rectal cancer with Volumetric Modulated Arc Therapy: summary of technical and dosimetric features and early clinical experience about?
## Abstract ## Background To report about initial technical and clinical experience in preoperative radiation treatment of rectal cancer with volumetric modulated arcs with the RapidArc^®^ (RA) technology. ## Methods Twenty-five consecutive patients (pts) were treated with RA. All showed locally advanced rectal adenocarcinoma with stage T2-T4, N0-1. Dose prescription was 44 Gy in 22 fractions (or 45 Gy in 25 fractions). Delivery was performed with single arc with a 6 MV photon beam. Twenty patients were treated preoperatively, five did not receive surgery. Twenty-three patients received concomitant chemotherapy with oral capecitabine. A comparison with a cohort of twenty patients with similar characteristics treated with conformal therapy (3DC) is presented as well. ## Results From a dosimetric point of view, RA improved conformality of doses (CI~95%~ = 1.1 vs. 1.4 for RA and 3DC), presented similar target coverage with lower maximum doses, significant sparing of femurs and significant reduction of integral and mean dose to healthy tissue. From the clinical point of view, surgical reports resulted in a down-staging in 41% of cases. Acute toxicity was limited to Grade 1-2 diarrhoea
Who reads Neo-adjuvant chemo-radiation of rectal cancer with Volumetric Modulated Arc Therapy: summary of technical and dosimetric features and early clinical experience?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Antonella Richetti; Antonella Fogliata; Alessandro Clivio; Giorgia Nicolini; Gianfranco Pesce; Emanuela Salati; Eugenio Vanetti; Luca Cozzi
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2006-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1748-717X)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)