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Global Incidence of and Trends in Intrahepatic and Extrahepatic Cholangiocarcinoma from 1993 to 2012 by Florio, Andrea A.; Ferlay, Jacques; Znaor, Ariana; Ruggieri, David; Alvarez, Christian S.; Laversanne, Mathieu; Bray, Freddie; McGlynn, Katherine A.; Petrick, Jessica L. is a Medicine article available to read on EtoBox.
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## Background Intrahepatic cholangiocarcinomas (ICCs) and extrahepatic cholangiocarcinomas (ECCs) are highly lethal bile duct tumors. Their incidence can be difficult to estimate because of changes in cancer coding over time. No studies to date have examined their global incidence and trends with high‐quality topography‐ and histology‐specific cancer registry data. Therefore, this study examined ICC and ECC incidence with the Cancer Incidence in Five Continents Plus database. ## Methods Regional and national cancer registry data were used to estimate age‐standardized incidence rates (ASRs) per 100,000 person‐years, 95% confidence intervals, and average annual percent changes (AAPCs) for ICC in 38 countries and for ECC in 33 countries from 1993 to 2012. ICC and ECC trends were tabulated and plotted by country. Rates versus birth cohort by age were plotted, and an age‐period‐cohort analysis was performed to assess age and cohort incidence rate ratios. ## Results The highest rates of ICC and ECC were in Asia, specifically South Korea (ASR for ICC, 2.80; ASR for ECC, 2.24), Thailand (ASR for ICC, 2.19; ASR for ECC, 0.71), and Japan (ASR for ICC, 0.95; ASR for ECC, 0.83). Between 1993 a
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- Author
- Florio, Andrea A.; Ferlay, Jacques; Znaor, Ariana; Ruggieri, David; Alvarez, Christian S.; Laversanne, Mathieu; Bray, Freddie; McGlynn, Katherine A.; Petrick, Jessica L.
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)