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Comparison of the Antimicrobial Efficacy of Povidone-iodine-alcohol Versus Chlorhexidine-alcohol for Surgical Skin Preparation on the Aerobic and Anaerobic Skin Flora of the Shoulder Region by Dörfel, Dorothea (author);Maiwald, Matthias (author);Daeschlein, Georg (author);Müller, Gerald (author);Hudek, Robert (author);Assadian, Ojan (author);Kampf, Günter (author);Kohlmann, Thomas (author);Harnoss, Julian Camill (author);Kramer, Axel (author) is a Medicine article available to read on EtoBox.

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## Abstract ## Background Cutibacterium acnes is part of the anaerobic skin microbiome and resides in deeper skin layers. The organism is an agent of surgical site infections (SSI) in shoulder surgery. We hypothesized that prolonged skin preparation with an agent that penetrates deeply into the skin would be beneficial. Thus, we compared two classes of antiseptics, each combined with alcohol, each applied with two different contact times. ## Methods Using a cross-over arrangement, shoulders of 16 healthy volunteers were treated for 2.5 min (standard) or 30 min (prolonged) with alcohol-based chlorhexidine (CHG-ALC) or alcohol-based povidone-iodine (PVP-I-ALC). Skin sites were sampled before, immediately after, and 3 h after treatment, using a standardized cup-scrub technique. ## Results Aerobic skin flora was reduced more effectively by PVP-I-ALC than by CHG-ALC after 2.5 min application and immediate sampling (reduction factor [RF] 2.55 ± 0.75 vs. 1.94 ± 0.91, p = 0.04), but not after prolonged contact times and 3-h sampling. Coagulase-negative staphylococci were completely eliminated after PVP-I-ALC application, but still recovered from 4 of 32 samples after CHG-ALC application. A

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Author

Dörfel, Dorothea (author);Maiwald, Matthias (author);Daeschlein, Georg (author);Müller, Gerald (author);Hudek, Robert (author);Assadian, Ojan (author);Kampf, Günter (author);Kohlmann, Thomas (author);Harnoss, Julian Camill (author);Kramer, Axel (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)