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Lower Airway Obstruction, Bronchial Hyperresponsiveness, and Primary Pulmonary Hypertension in Children by Deepa Rastogi; Pakkay Ngai; Robyn J. Barst; Anastassios C. Koumbourlis is a Medicine article available to read on EtoBox.

What is Lower Airway Obstruction, Bronchial Hyperresponsiveness, and Primary Pulmonary Hypertension in Children about?

## Abstract We investigated the prevalence and reversibility of lower airway obstruction (LAO) and its correlation with pulmonary artery pressure in children with primary pulmonary hypertension (PPH). The analysis was performed retrospectively in a cohort of children with PPH between 5–18 years of age. PPH was defined as mean pulmonary artery pressure (PAPm) >25 mmHg at rest, or >30 mmHg during exercise, with normal pulmonary capillary wedge pressure in the absence of other causes. Lower airway function was assessed by spirometry and maximal expiratory flow‐volume curves. Lung volumes were measured by body plethysmography. Patients were assigned according to their pattern of lung function into “normal,” “obstructive,” and “restrictive” groups. The reversibility of LAO was defined as an increase of ≥15% from baseline in forced expiratory volume at 1 sec (FEV~1~) and/or ≥20% in forced expiratory flow at 25–75% of forced vital capacity (FEF~25–75%~) in response to nebulized albuterol. An “obstructive” pattern was found in 23 children (59%), a “restrictive” pattern in 2 children (5%), and a “normal” pattern in 14 children (36%). Response to bronchodilator was documented in 78% of child

Who reads Lower Airway Obstruction, Bronchial Hyperresponsiveness, and Primary Pulmonary Hypertension in Children?

Author

Deepa Rastogi; Pakkay Ngai; Robyn J. Barst; Anastassios C. Koumbourlis

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 8755-6863)

Published

2003

Language

EN

Field

Medicine (Health Sciences)