About this document
TPMT Variants and Drug Dosage Risks by veljacasper is a document available to read on EtoBox.
TPMT is an enzyme involved in the metabolism of immunosuppressant and anticancer drugs like azathioprine, 6-mercaptopurine, and 6-thioguanine. Approximately 10% of individuals have reduced TPMT enzyme activity due to genetic variants, putting them at higher risk for bone marrow toxicity from these drugs. Patients with acute lymphoblastic leukemia (ALL) who have TPMT deficiency have shown severe hematopoietic toxicity when treated with standard doses of 6-mercaptopurine, a key drug in ALL therapy regimens. T
- Author
- veljacasper
- Language
- EN