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Effect of L-tetrahydropalmatine on Dopamine Release and Metabolism in the Rat Striatum by Françoise Marcenac; Guo Zhang Jin; François Gonon is a Neuroscience article available to read on EtoBox.

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In vivo voltammetric measurements of striatal extracellular DOPAC concentrations and of striatal DA release in combination with post-mortem analysis of striatal catechols were performed in the rat to study the effects on the nigro-striatal neurons of a Chinese neuroleptic, ltetrahydropalmatine (/-THP), which is known to block post-synaptic dopaminergic receptors. /-THP injected at doses that cause sedation in rats and mice (5-10 mg/kg) induced a marked increase in post-mortem DOPAC levels (+ 250%), while no significant effect was observed on postmortem DA levels. The extracellular DOPAC concentration was increased to 155\_\_\_9% of the control value after /-THP administration (1 mg/kg, IP). Further, an injection of/-THP (1 mg/kg, IP) induced an increase in extracellular DA concentration (220% of the basal value), reversed the decrease in extracellular DA concentration induced by apomorphine (0.05 mg/kg, SC) and enhanced the effects of the electrical stimulation of the nigro-striatal pathway. These results confirm that /-THP acts on the nigro-striatal neurons as a dopaminergic antagonist that can block both postand presynaptic receptors.

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Author

Françoise Marcenac; Guo Zhang Jin; François Gonon

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0033-3158)

Published

1985

Language

EN

Field

Neuroscience (Life Sciences)