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Lack of Support for the Genes by Early Environment Interaction Hypothesis in the Pathogenesis of Schizophrenia by Evangelos Vassos; Jiaqi Kou; Sarah Tosato; Jessye Maxwell; Charlotte A Dennison; Sophie E Legge; James T R Walters; Michael J Owen; Michael C O’Donovan; Gerome Breen; Cathryn M Lewis; Patrick F Sullivan; Christina Hultman; Mirella Ruggeri; Muriel Walshe; Elvira Bramon; Sarah E Bergen; Robin M Murray is a Medicine article available to read on EtoBox.
What is Lack of Support for the Genes by Early Environment Interaction Hypothesis in the Pathogenesis of Schizophrenia about?
## Abstract Ursini et al reported recently that the liability of schizophrenia explained by a polygenic risk score (PRS) derived from the variants most associated with schizophrenia was increased 5-fold in individuals who experienced complications during pregnancy or birth. Follow-up gene expression analysis showed that the genes mapping to the most associated genetic variants are highly expressed in placental tissues. If confirmed, these findings will have major implications in our understanding of the joint effect of genes and environment in the pathogenesis of schizophrenia. We examined the interplay between PRS and obstetric complications (OCs) in 5 independent samples (effective N = 2110). OCs were assessed with the full or modified Lewis-Murray scale, or with birth weight < 2.5 kg as a proxy. In a large cohort we tested whether the pathways from placenta-relevant variants in the original report were associated with case-control status. Unlike in the original study, we did not find significant effect of PRS on the presence of OCs in cases, nor a substantial difference in the association of PRS with case-control status in samples stratified by the presence of OCs. Furthermore,
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- Author
- Evangelos Vassos; Jiaqi Kou; Sarah Tosato; Jessye Maxwell; Charlotte A Dennison; Sophie E Legge; James T R Walters; Michael J Owen; Michael C O’Donovan; Gerome Breen; Cathryn M Lewis; Patrick F Sullivan; Christina Hultman; Mirella Ruggeri; Muriel Walshe; Elvira Bramon; Sarah E Bergen; Robin M Murray
- Publisher
- Oxford University Press (OUP)
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)