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This document presents a green protocol for the catalyst-free synthesis of 1-oxo-hexahydroxanthenes using salicylaldehyde and cyclohexane-1,3-dione or dimedone in water. The method is characterized by excellent product yields, operational simplicity, and environmental friendliness, aligning with green chemistry principles. The synthesis is achieved under reflux conditions without the need for catalysts, making it a practical and economical alternative to traditional methods.
- Author
- paloma abrantes
- Language
- EN