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The utility of performing the initial lumbar puncture on day 8 in remission induction therapy for childhood acute lymphoblastic leukemia: TCCSG L99-15 study by Daisuke Hasegawa; Atsushi Manabe; Akira Ohara; Akira Kikuchi; Katsuyoshi Koh; Nobutaka Kiyokawa; Takashi Fukushima; Yasushi Ishida; Tomohiro Saito; Ryoji Hanada; Masahiro Tsuchida; The Tokyo Children's Cancer Study Group is a Medicine article available to read on EtoBox.
What is The utility of performing the initial lumbar puncture on day 8 in remission induction therapy for childhood acute lymphoblastic leukemia: TCCSG L99-15 study about?
## Abstract ## Background Traumatic lumbar puncture with leukemic blasts (TLP+), which has been reported to occur 5–10%, in the previous studies, adversely affects the outcome of children with acute lymphoblastic leukemia (ALL). Based on the results from our previous study, we deferred the initial lumbar puncture until day 8 in remission induction therapy in order to reduce the frequency of cases with TLP+. ## Procedure The study was conducted as a prospective cohort study within the Tokyo Children's Cancer Study Group (TCCSG) L99‐15 study. Between April 1999 and June 2003, 754 children with newly diagnosed ALL enrolled. The patients received the initial intrathecal chemotherapy after 7 days of prednisolone treatment. The incidence of central nervous system (CNS)‐positive (the presence of leukemic blasts in cerebrospinal fluid or cranial nerve palsy) including TLP+ cases and cumulative incidence of CNS relapse were examined. ## Results The incidence of CNS‐positive and TLP+ was 2.9% (n = 22) and 0.8% (n = 6), respectively. These incidences were much lower than those in the representative study groups employing the initial IT on day 1. Of 22 patients with CNS‐positive, only one pati
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- Author
- Daisuke Hasegawa; Atsushi Manabe; Akira Ohara; Akira Kikuchi; Katsuyoshi Koh; Nobutaka Kiyokawa; Takashi Fukushima; Yasushi Ishida; Tomohiro Saito; Ryoji Hanada; Masahiro Tsuchida; The Tokyo Children's Cancer Study Group
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)