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A Systematic Review of the Colorectal Microbiome in Adult Cystic Fibrosis Patients by Brent Gilbert; Gerard Kaiko; Stephen Smith; Peter Wark is a Medicine article available to read on EtoBox.

What is A Systematic Review of the Colorectal Microbiome in Adult Cystic Fibrosis Patients about?

Aim Cystic fibrosis (CF) is a hereditary, life-limiting, multi-system condition that results in chronic respiratory infections, pancreatic insufficiency and intestinal inflammation. Evidence indicates that CF patients develop colorectal cancer (CRC) earlier and more often than the general population. Intestinal dysbiosis resulting from genetics and CF treatment is a contributing factor. This systematic review aims to evaluate the literature to compare the microbiome of adult CF patients to non-CF patients and to assess if these changes correspond with known CRC microbiome alterations. Methods A systematic review across five databases was performed according to PRISMA guidelines. Studies focusing on adult CF patients using next generation sequencing and with appropriate non-CF controls were included. Two reviewers independently screened results and assessed study quality using the Newcastle–Ottawa scale. Results The search generated 2757 results. 118 studies were retained after reviewing the title/abstract and full article review found five studies met the inclusion criteria. All studies consistently showed reduced microbial diversity in CF patients and unique clustering between CF

Who reads A Systematic Review of the Colorectal Microbiome in Adult Cystic Fibrosis Patients?

Author

Brent Gilbert; Gerard Kaiko; Stephen Smith; Peter Wark

Publisher

Wiley

Published

2023

Language

EN

Field

Medicine (Health Sciences)