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Can I read Evidence-based Selection of Training Compounds for Use in the Mechanism-based Integrated Prediction of Drug-induced Liver Injury in Man on EtoBox?
Evidence-based Selection of Training Compounds for Use in the Mechanism-based Integrated Prediction of Drug-induced Liver Injury in Man by Sanja Dragovic; Nico P. E. Vermeulen; Helga H. Gerets; Philip G. Hewitt; Magnus Ingelman‐Sundberg; B. Kevin Park; Satu Juhila; Jan Snoeys; Richard J. Weaver is a Environmental Science article available to read on EtoBox.
What is Evidence-based Selection of Training Compounds for Use in the Mechanism-based Integrated Prediction of Drug-induced Liver Injury in Man about?
The current test systems employed by pharmaceutical industry are poorly predictive for drug-induced liver injury (DILI). The 'MIP-DILI' project addresses this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological relevance to DILI in humans. An iterative, tiered approach with respect to test compounds, test systems, bioanalysis and systems analysis is adopted to evaluate existing models and develop new models that can provide validated test systems with respect to the prediction of specific forms of DILI and further elucidation of mechanisms. An essential component of this effort is the choice of compound training set that will be used to inform refinement and/or development of new model systems that allow prediction based on knowledge of mechanisms, in a tiered fashion. In this review, we focus on the selection of MIP-DILI training compounds for mechanism-based evaluation of non-clinical prediction of DILI. The selected compounds address both hepatocellular and cholestatic DILI patterns in man, covering a broad range of pharmacologies and chemistries, and taking into account availab
Who reads Evidence-based Selection of Training Compounds for Use in the Mechanism-based Integrated Prediction of Drug-induced Liver Injury in Man?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Sanja Dragovic; Nico P. E. Vermeulen; Helga H. Gerets; Philip G. Hewitt; Magnus Ingelman‐Sundberg; B. Kevin Park; Satu Juhila; Jan Snoeys; Richard J. Weaver
- Publisher
- Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0340-5761)
- Published
- 2016
- Language
- EN
- Field
- Environmental Science (Life Sciences)