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Cucurbit[10]uril-based supramolecular radicals: Powerful arms to kill facultative anaerobic bacteria by Dan Wu; Zhankui Zhang; Xinyue Li; Jin Han; Qinglian Hu; Yuan Yu; Zhengwei Mao is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Cucurbit[10]uril-based supramolecular radicals: Powerful arms to kill facultative anaerobic bacteria about?

Two water-soluble supramolecular complexes (CB[10]⊃PSA and CB[10]⊃TPE-cyc) are constructed based on the host–guest interaction between cucurbit[10]uril (CB[10]) and perylene diimide derivative (PSA) or tetracationic cyclophane (TPE-cyc). Attributing to the matched redox potential, both supramolecular complexes can be specifically reduced into corresponding supramolecular radical cations or anions by facultative anaerobic E. coli. Benefiting from the strong near-infrared (NIR) absorption, CB[10]⊃PSA radical anions and CB[10]⊃TPE-cyc radical cations act as efficient NIR photosensitizers and perform an excellent antimicrobial activity (close to 100%) via PTT. In addition, the biocompatibility of TPE-cyc is notably improved under the protection of CB[10], guaranteeing its biosafety for in vivo application. CB[10]⊃PSA radical anions and CB[10]⊃TPE-cyc radical cations are in situ generated in the E. coli-infected abscess of mice and effectively inhibit the bacterial infection without obvious system toxicity. It is anticipated that this supramolecular strategy may pave a new way for the selective bacteria inhibition to regulate the balance of different bacterial flora.

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Author

Dan Wu; Zhankui Zhang; Xinyue Li; Jin Han; Qinglian Hu; Yuan Yu; Zhengwei Mao

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)