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Can I read The Protective Effects of Acetazolamide Against Homocysteine-Induced Blood–Brain-Barrier Disruption by Regulating the Activation of the Wnt/β-Catenin Signaling Pathway on EtoBox?
The Protective Effects of Acetazolamide Against Homocysteine-Induced Blood–Brain-Barrier Disruption by Regulating the Activation of the Wnt/β-Catenin Signaling Pathway by Chuo Li; Bo Zhang is a Neuroscience article available to read on EtoBox.
What is The Protective Effects of Acetazolamide Against Homocysteine-Induced Blood–Brain-Barrier Disruption by Regulating the Activation of the Wnt/β-Catenin Signaling Pathway about?
Acetazolamide (AZA) is a carbonic anhydrase inhibitor (CAI) with neuroprotective effects. Hyperhomocysteinemia is associated with blood-brain-barrier (BBB) disruption in brain disorders. A previous study indicated that AZA might have a new role in brain disorders. However, its function in hyperhomocysteinemia-related BBB disruption has not been reported. Here, we aim to clarify the role of AZA in homocysteine (Hcy)-mediated BBB dysfunction using both in vivo and in vitro assays. We found that AZA improved memory and cognitive function, and reduced brain edema in Hcy-stimulated hyperhomocysteinemia model rats. This protective effect of AZA on hyperhomocysteinemia rats was accompanied by improved BBB permeability and increased expression levels of the tight junction proteins, occludin, and claudin-5. The in vitro assay results show that AZA prevented Hcy-induced cell injury and attenuated the increased permeability in Hcy-treated bEnd.3 brain endothelial cells. The Hcy-induced decrease in occludin and claudin-5, and increase in MMP-2 and MMP-9 expression levels were attenuated by AZA in bEnd.3 cells. Moreover, the Hcy-induced downregulation of the Wnt/β-catenin signaling pathway in b
Who reads The Protective Effects of Acetazolamide Against Homocysteine-Induced Blood–Brain-Barrier Disruption by Regulating the Activation of the Wnt/β-Catenin Signaling Pathway?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Chuo Li; Bo Zhang
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Neuroscience (Life Sciences)