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Can I read Association of Alcohol in Brain Injury, Headaches, and Stroke with Brain–Tissue and Serum Levels of Ionized Magnesium: A Review of Recent Findings and Mechanisms of Action on EtoBox?
Association of Alcohol in Brain Injury, Headaches, and Stroke with Brain–Tissue and Serum Levels of Ionized Magnesium: A Review of Recent Findings and Mechanisms of Action by Burton M Altura; Bella T Altura is a Medicine article available to read on EtoBox.
What is Association of Alcohol in Brain Injury, Headaches, and Stroke with Brain–Tissue and Serum Levels of Ionized Magnesium: A Review of Recent Findings and Mechanisms of Action about?
Although there is general agreement that chronic ingestion of alcohol poses great risks for normal cardiovascular functions and peripheral-vascular homeostasis, a direct cause and effect between the real phenomena of alcohol-induced headache and risk of brain injury and stroke is not appreciated. "Binge drinking" of alcohol is associated with an ever-growing number of strokes and sudden death. It is becoming clear that alcohol ingestion can result in profoundly different actions on the cerebral circulation (e.g., vasodilation, vasoconstriction-spasm, vessel rupture), depending upon dose and physiologic state of host. Using rats, it has been demonstrated that acute, high doses of ethanol can result in stroke-like events concomitant with alterations in brain bioenergetics. We review recent in vivo findings obtained with 31 P-NMR spectroscopy, optical reflectance spectroscopy, and direct in vivo microcirculatory studies on the intact brain. Alcohol-induced hemorrhagic stroke is preceded by a rapid fall in brain intracellular free magnesium ions ([Mg 2 ϩ ] i ) followed by cerebrovasospasm and reductions in phosphocreatine (PCr)/ATP ratio, intracellular pH, and the cytosolic phosphoryla
Who reads Association of Alcohol in Brain Injury, Headaches, and Stroke with Brain–Tissue and Serum Levels of Ionized Magnesium: A Review of Recent Findings and Mechanisms of Action?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Burton M Altura; Bella T Altura
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0741-8329)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)