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Can I read A Combination of Neurofilament Light, Glial Fibrillary Acidic Protein, and Neuronal Pentraxin-2 Discriminates Between Frontotemporal Dementia and Other Dementias on EtoBox?
A Combination of Neurofilament Light, Glial Fibrillary Acidic Protein, and Neuronal Pentraxin-2 Discriminates Between Frontotemporal Dementia and Other Dementias by Katharina Bolsewig; Yanaika S. Hok-A-Hin; Federica N. Sepe; Lynn Boonkamp; Dirk Jacobs; Giovanni Bellomo; Federico Paolini Paoletti; Eugeen Vanmechelen; Charlotte E. Teunissen; Lucilla Parnetti; Eline A. J. Willemse is a Medicine article available to read on EtoBox.
What is A Combination of Neurofilament Light, Glial Fibrillary Acidic Protein, and Neuronal Pentraxin-2 Discriminates Between Frontotemporal Dementia and Other Dementias about?
## Background: The differential diagnosis of frontotemporal dementia (FTD) is still a challenging task due to its symptomatic overlap with other neurological diseases and the lack of biofluid-based biomarkers. ## Objective: To investigate the diagnostic potential of a combination of novel biomarkers in cerebrospinal fluid (CSF) and blood. ## Methods: We included 135 patients from the Center for Memory Disturbances, University of Perugia, with the diagnoses FTD (__n__ = 37), mild cognitive impairment due to Alzheimer’s disease (MCI-AD, __n__ = 47), Lewy body dementia (PDD/DLB, __n__ = 22), and cognitively unimpaired patients as controls (OND, __n__ = 29). Biomarker levels of neuronal pentraxin-2 (NPTX2), neuronal pentraxin receptor, neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) were measured in CSF, as well as NfL and GFAP in serum. We assessed biomarker differences by analysis of covariance and generalized linear models (GLM). We performed receiver operating characteristics analyses and Spearman correlation to determine biomarker associations. ## Results: CSF NPTX2 and serum GFAP levels varied most between diagnostic groups. The combination of CSF NPTX2, seru
Who reads A Combination of Neurofilament Light, Glial Fibrillary Acidic Protein, and Neuronal Pentraxin-2 Discriminates Between Frontotemporal Dementia and Other Dementias?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Katharina Bolsewig; Yanaika S. Hok-A-Hin; Federica N. Sepe; Lynn Boonkamp; Dirk Jacobs; Giovanni Bellomo; Federico Paolini Paoletti; Eugeen Vanmechelen; Charlotte E. Teunissen; Lucilla Parnetti; Eline A. J. Willemse
- Publisher
- IOS Press
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)