About this Biochemistry, Genetics and Molecular Biology article
Increased Bone Mass in Mice after Single Injection of Anti-receptor Activator of Nuclear Factor-κB Ligand-neutralizing Antibody by Yuriko Furuya; Kaoru Mori; Tadashi Ninomiya; Yoshiya Tomimori; Sakae Tanaka; Naoyuki Takahashi; Nobuyuki Udagawa; Kohji Uchida; Hisataka Yasuda is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
**Background:** Receptor activator of nuclear factor-κB ligand is a pivotal osteoclast differentiation factor. **Results:** Daily injection of parathyroid hormone increased bone mass by stimulating bone formation in the anti-receptor activator of nuclear factor-κB ligand antibody-treated mice. **Conclusion:** Parathyroid hormone exerted its bone anabolic activity in mice with few osteoclasts. **Significance:** Parathyroid hormone requires no osteoclasts for stimulating bone formation.
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- Author
- Yuriko Furuya; Kaoru Mori; Tadashi Ninomiya; Yoshiya Tomimori; Sakae Tanaka; Naoyuki Takahashi; Nobuyuki Udagawa; Kohji Uchida; Hisataka Yasuda
- Publisher
- The American Society for Biochemistry and Molecular Biology; American Society for Biochemistry and Molecular Biology; American Society for Biochemistry and Molecular Biology Inc.; American Society for Biochemistry & Molecular Biology (ASBMB); Elsevier BV (ISSN 0021-9258)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)