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Non‐Hodgkin lymphoma and autoimmunity: Does gender matter? by Pat Ansell; Jill Simpson; Tracy Lightfoot; Alex Smith; Eleanor Kane; Debra Howell; Rob Newton; Dennis McGonagle; Andrew Jack; Eve Roman is a Medicine article available to read on EtoBox.

## Abstract Autoimmune disorders are more frequent in women, whereas most non‐Hodgkin lymphomas (NHLs) are common in men; yet, sex‐specific autoimmune–lymphoma associations are rarely reported. Detailed data on autoimmune disease were abstracted from medical records of 791 cases (including 316 diffuse large B‐cell lymphomas (DLBCLs); 228 follicular lymphomas (FLs); 127 marginal zone lymphomas (MZLs); 64 T‐cell lymphomas and 38 mantle cell lymphomas) and 872 controls. The combined prevalence of autoimmune disease was higher among women (15.7% controls; 19.7% cases) than men (6.6% controls; 14.5% cases), but the overall association with NHL was stronger for men (odds ratio 2.4, 95% confidence interval: 1.5–3.8) than women (1.3, 0.9–1.9), the disparity persisting when data for the year immediately preceding lymphoma diagnosis were excluded (men 2.0, 1.3–3.3; women 1.2, 0.8–1.8). For both sexes, the strongest individual associations were for DLBCL, MZL and T‐cell lymphomas, with no associations evident for FL. Among women, there were strong links between MZL and both Sjögren's syndrome and idiopathic thrombocytopenia, and among men, between DLBCL and both rheumatoid arthritis and Crohn

Author

Pat Ansell; Jill Simpson; Tracy Lightfoot; Alex Smith; Eleanor Kane; Debra Howell; Rob Newton; Dennis McGonagle; Andrew Jack; Eve Roman

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2010

Language

EN

Field

Medicine (Health Sciences)