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Distribution of Glutamate Receptor Subunits at Neurochemically Characterized Synapses in the Entopeduncular Nucleus and Subthalamic Nucleus of the Rat by N.P. Clarke; J.P. Bolam is a Neuroscience article available to read on EtoBox.
What is Distribution of Glutamate Receptor Subunits at Neurochemically Characterized Synapses in the Entopeduncular Nucleus and Subthalamic Nucleus of the Rat about?
Glutamatergic neurotransmission in the subthalamic nucleus (STN) and in the output nuclei of the basal ganglia is critical in the expression of basal ganglia function, and increased glutamate transmission in these nuclei has been implicated in the pathology of Parkinson's disease. In order to determine the precise spatial relationship of subunits of the ␣-amino-3hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and N-methyl-D-aspartate (NMDA) glutamate receptors to nerve terminals enriched in glutamate or ␥-aminobutyric acid (GABA) in one of the output nuclei, the entopeduncular nucleus (EP), and the STN, postembedding immunolabelling for glutamate receptor subunits and for glutamate and GABA was carried out in the rat. Immunolabelling for the AMPA glutamate receptor subunits 1, 2/3, and 4 (GluR1, GluR2/3, and GluR4) and the NMDA receptor subunit 1 (NR1) was localized predominantly within asymmetrical synapses in both the EP and STN. Quantitative analysis revealed that, on average for the whole population, each of the receptor subunits was evenly distributed along the synaptic specialization. Multiple AMPA receptor subunits and the GluR2/3 and NMDA (NR1) subunits were co-localized with
Who reads Distribution of Glutamate Receptor Subunits at Neurochemically Characterized Synapses in the Entopeduncular Nucleus and Subthalamic Nucleus of the Rat?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- N.P. Clarke; J.P. Bolam
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)
- Published
- 1998
- Language
- EN
- Field
- Neuroscience (Life Sciences)