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The impact of high-intensity interval exercise training on NK-cell function and circulating myokines for breast cancer prevention among women at high risk for breast cancer by Adriana M. Coletta; Nadia H. Agha; Forrest L. Baker; Grace M. Niemiro; Preteesh L. Mylabathula; Abenaa M. Brewster; Therese B. Bevers; Enrique Fuentes-Mattei; Karen Basen-Engquist; Susan C. Gilchrist; Richard J. Simpson is a Medicine article available to read on EtoBox.

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## Purpose Preclinical evidence suggests that natural killer cell (NK-cell) function and myokines facilitate the protective effects of exercise for breast cancer prevention. Since higher-intensity exercise acutely promotes greater mobilization and larger changes in NK-cell cytotoxicity than lower-intensity, high-intensity interval training (HIIT) might offer increased immune protection compared to moderate-intensity continuous-training (MICT). This study compared a 12-week HIIT program to a 12-week MICT program and usual care on changes in resting NK-cell function and circulating myokines among women at high risk for breast cancer. ## Methods Thirty-three women were randomized to HIIT, MICT, or usual care, for a supervised exercise intervention. Blood was collected at baseline and end-of-study. The cytotoxic activity of CD3−/CD56+ NK-cells against the K562 target cell line in vitro was determined by flow cytometry. Circulating myokines (IL-15, IL-6, irisin, OSM, osteonectin, IL-7) were assessed with luminex multiplex assays and ELISA. One-way ANOVA and paired sample t-tests assessed between- and within-group differences, respectively. Pearson correlation coefficients determined rel

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Author

Adriana M. Coletta; Nadia H. Agha; Forrest L. Baker; Grace M. Niemiro; Preteesh L. Mylabathula; Abenaa M. Brewster; Therese B. Bevers; Enrique Fuentes-Mattei; Karen Basen-Engquist; Susan C. Gilchrist; Richard J. Simpson

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)