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Can I read Transfusion‐associated GVHD after fludarabine therapy in a patient with systemic lupus erythematosus on EtoBox?
Transfusion‐associated GVHD after fludarabine therapy in a patient with systemic lupus erythematosus by Susan F. Leitman; John F. Tisdale; Charles D. Bolan; Mark A. Popovsky; John H. Klippel; James E. Balow; Dimitrios T. Boumpas; Gabor G. Illei is a Medicine article available to read on EtoBox.
What is Transfusion‐associated GVHD after fludarabine therapy in a patient with systemic lupus erythematosus about?
**BACKGROUND:** Fludarabine, a purine antimetabolite with potent immunosuppressive properties, has previously been associated with the development of transfusion‐associated GVHD (TA‐GVHD) in patients with hematologic malignancies. Its role as a risk factor for TA‐GVHD in patients without underlying leukemia or lymphoma is uncertain. **STUDY DESIGN AND METHODS:** A 42‐year‐old female with refractory lupus nephritis received three monthly cycles of fludarabine (30 mg/m^2^/day on Days 1‐3) and cyclophosphamide (500 mg/m^2^ on Day 1). Three months after the last dose of fludarabine, she received 2 units of packed RBCs and 6 units of pooled random platelets, none of which were irradiated. Two weeks later, fever, rash, aminotransferase elevations, hyperbilirubinemia, and pancytopenia developed. **RESULTS:** Marrow biopsy showed severe aplasia and skin biopsy was consistent with GVHD. Allele‐level HLA typing on circulating lymphocytes revealed extra HLA alleles not present in her pretreatment sample, but identical to the HLA haplotypes of an unrelated platelet donor. Treatment with antithymocyte globulin, cyclosporine, and prednisone was followed by preparatory conditioning for a PBPC tra
Who reads Transfusion‐associated GVHD after fludarabine therapy in a patient with systemic lupus erythematosus?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Susan F. Leitman; John F. Tisdale; Charles D. Bolan; Mark A. Popovsky; John H. Klippel; James E. Balow; Dimitrios T. Boumpas; Gabor G. Illei
- Publisher
- Elsevier Science; John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Elsevier; Elsevier BV; Wiley (ISSN 0372-1248)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)