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A Randomised Controlled Trial with Prolonged‐release Oral Oxycodone and Naloxone to Prevent and Reverse Opioid‐induced Constipation by Winfried Meissner; Petra Leyendecker; Stefan Mueller‐Lissner; Joachim Nadstawek; Michael Hopp; Christian Ruckes; Stefan Wirz; Wolfgang Fleischer; Karen Reimer is a Medicine article available to read on EtoBox.

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## ABSTRACT __Background:__ Opioid‐induced constipation can have a major negative impact on patients’ quality of life. This randomised, double‐blinded study evaluated the analgesic efficacy of prolonged‐release (PR) oral oxycodone when co‐administered with PR oral naloxone, and its impact on opioid‐induced constipation in patients with severe chronic pain. Another objective was to identify the optimal dose ratio of oxycodone and naloxone. __Methods:__ A total of 202 patients with chronic pain (mainly non‐cancer related, 2.5% of patients had cancer‐related pain) under stable oral oxycodone therapy (40, 60 or 80mg/day) were randomised to receive 10, 20, 40mg/day naloxone or placebo. After a 4‐week maintenance phase, patients received oxycodone only for 2 weeks. Pain intensity was evaluated using a numerical analogue scale and bowel function was assessed using the bowel function index. __Results:__ No loss of analgesic efficacy with naloxone was observed. Mean pain intensity scores on randomisation were comparable for placebo, 10mg, 20mg and 40mg naloxone dose, and remained unchanged during treatment. Bowel function improved with increasing naloxone dose. Naloxone 20mg and 40mg signif

Who reads A Randomised Controlled Trial with Prolonged‐release Oral Oxycodone and Naloxone to Prevent and Reverse Opioid‐induced Constipation?

Author

Winfried Meissner; Petra Leyendecker; Stefan Mueller‐Lissner; Joachim Nadstawek; Michael Hopp; Christian Ruckes; Stefan Wirz; Wolfgang Fleischer; Karen Reimer

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; FASEB (ISSN 1090-3801)

Published

2009

Language

EN

Field

Medicine (Health Sciences)