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Can I read Endocrine Disruptors of Inhibiting Testicular 3β-Hydroxysteroid Dehydrogenase on EtoBox?
Endocrine Disruptors of Inhibiting Testicular 3β-Hydroxysteroid Dehydrogenase by Song Zhang; Jiaying Mo; Yiyan Wang; Chaobo Ni; Xiaoheng Li; Qiqi Zhu; Ren-Shan Ge is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Endocrine Disruptors of Inhibiting Testicular 3β-Hydroxysteroid Dehydrogenase about?
Testicular 3β-hydroxysteroid dehydrogenase (HSD3B) is a steroidogenic enzyme, catalyzing the conversion of 3β-hydroxysteroids into 3-keto-steroids. Two distinct isoforms in the human are cloned, HSD3B1 and HSD3B2, and HSD3B2 is located in the testis. HSD3B2 is a two-substrate enzyme, which binds to cofactor NAD+ and a 3β-steroid. Many endocrine disruptors, including industrial compounds (phthalates, bisphenols, and perfluoroalkyl substances), insecticides and biocides (organochlorine insecticides and organotins), food additives (butylated hydroxyanisole, resveratrol, gossypol, flavones, and isoflavones), and drugs (etomidate, troglitazone, medroxyprogesterone acetate, and ketoconazole) inhibit testicular HSD3B, possibly interfering with androgen synthesis. In this review, we discuss the distinct testicular isoform of HSD3B, its gene, chemistry, subcellular location, and the endocrine disruptors that directly inhibit testicular HSD3B and their inhibitory modes.
Who reads Endocrine Disruptors of Inhibiting Testicular 3β-Hydroxysteroid Dehydrogenase?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Song Zhang; Jiaying Mo; Yiyan Wang; Chaobo Ni; Xiaoheng Li; Qiqi Zhu; Ren-Shan Ge
- Publisher
- Elsevier BV
- Published
- 2019
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)