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Metabolic and Toxic Myelopathies by Natalie Elizabeth Parks is a Medicine article available to read on EtoBox.

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## ABSTRACT ## PURPOSE OF REVIEW This article describes the clinical presentation, relevant diagnostic investigations, and treatment of metabolic and toxic myelopathies. ## RECENT FINDINGS Metabolic myelopathies, including those due to deficiency of vitamin B~12~, folate, copper, or vitamin E, are preventable and typically respond to supplementation. In metabolic myelopathy, early recognition and treatment are important to reduce morbidity, particularly due to subacute combined degeneration of the spinal cord. Toxic myelopathies, including those due to medical interventions (eg, methotrexate, radiation), dietary toxins (eg, lathyrism, konzo), and drugs of abuse (eg, heroin), typically result in permanent neurologic deficits. Toxic myelopathy due to hepatic dysfunction may be reversible if patients receive early intervention, whereas nitrous oxide myelopathy responds to vitamin B~12~ replacement and cessation of exposure. In toxic myelopathy, it is best to avoid the provoking factor when possible or attempt to mitigate risk by identifying risk factors for developing myelopathy. ## SUMMARY Metabolic and toxic myelopathies are important causes of morbidity that require a high index of

Who reads Metabolic and Toxic Myelopathies?

Author

Natalie Elizabeth Parks

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2021

Language

EN

Field

Medicine (Health Sciences)