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Germline mutations in E‐cadherin do not explain association of hereditary prostate cancer, gastric cancer and breast cancer by Björn‐Anders Jonsson; Anders Bergh; Pär Stattin; Monika Emmanuelsson; Henrik Grönberg is a Medicine article available to read on EtoBox.

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## Abstract Somatic mutations in the __E‐cadherin__ (__CDH1__) gene have frequently been reported in cases with diffuse gastric and lobular breast cancers. Recently, germline mutations have been identified in families with diffuse gastric cancers. In families with hereditary prostate cancer (HPC), a significant association of prostate cancer, gastric and/or breast cancer has been observed in epidemiological studies. The aim of this study was to investigate if germline mutations in __CDH1__ could explain the risk for cancer in HPC families with an excess of gastric and breast cancer. In total, 17 members from 13 HPC families and 3 members from 3 families with hereditary gastric cancer (HGC) were screened for germline __CDH1__ sequence alterations using PCR/Denaturing HPLC for initial screening of nucleotide variants followed by confirmatory direct sequencing analysis. The frequency of identified novel germline mutations were tested for in 136 cases with hereditary prostate cancer and 215 cases of sporadic prostate cancer with 422 age matched controls in an allelic discrimination assay. In total, 8 sequence variants were detected in 20 samples tested. In the HPC families, we found 2

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Author

Björn‐Anders Jonsson; Anders Bergh; Pär Stattin; Monika Emmanuelsson; Henrik Grönberg

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2002

Language

EN

Field

Medicine (Health Sciences)