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Systemic sclerosis in childhood: Clinical and immunologic features of 153 patients in an international database by Giorgia Martini; Ivan Foeldvari; Ricardo Russo; Ruben Cuttica; Anne Eberhard; Angelo Ravelli; Thomas J. A. Lehman; Sheila Knupp Feitosa de Oliveira; Gordana Susic; Galina Lyskina; Dana Nemcova; Robert Sundel; Fernanda Falcini; Herman Girschick; Ana Paula Lotito; Antonella Buoncompagni; Flavio Sztajnbok; Sulaiman M. Al‐Mayouf; Ilonka Orbàn; Clodoveo Ferri; Balu H. Athreya; Patricia Woo; Francesco Zulian is a Medicine article available to read on EtoBox.
What is Systemic sclerosis in childhood: Clinical and immunologic features of 153 patients in an international database about?
## Abstract ## Objective To determine the clinical and immunologic features of systemic sclerosis (SSc) in a large group of children and describe the clinical evolution of the disease and compare it with the adult form. ## Methods Data on 153 patients with juvenile SSc collected from 55 pediatric rheumatology centers in Europe, Asia, and South and North America were analyzed. Demographic, clinical, and immunologic characteristics of children with juvenile SSc at the onset, at diagnosis, and during the disease course were evaluated. ## Results Raynaud's phenomenon was the most frequent symptom, followed by skin induration in ∼75% of patients. Musculoskeletal symptoms were present in one‐third of patients, and the most frequently involved internal organs were respiratory and gastrointestinal, while involvement of renal, cerebral, and cardiovascular systems was extremely rare. Antinuclear antibodies were present in the sera of 81% of patients. Anti–topoisomerase I (Scl‐70) and anticentromere antibodies were found to be positive in 34% and 7.1% of patients, respectively. Involvement of the respiratory, gastrointestinal, and cardiovascular systems was more frequent and occurred earlier
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- Author
- Giorgia Martini; Ivan Foeldvari; Ricardo Russo; Ruben Cuttica; Anne Eberhard; Angelo Ravelli; Thomas J. A. Lehman; Sheila Knupp Feitosa de Oliveira; Gordana Susic; Galina Lyskina; Dana Nemcova; Robert Sundel; Fernanda Falcini; Herman Girschick; Ana Paula Lotito; Antonella Buoncompagni; Flavio Sztajnbok; Sulaiman M. Al‐Mayouf; Ilonka Orbàn; Clodoveo Ferri; Balu H. Athreya; Patricia Woo; Francesco Zulian
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)