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An Overview on Glycation: Molecular Mechanisms, Impact on Proteins, Pathogenesis, and Inhibition by Ana Belén Uceda; Laura Mariño; Rodrigo Casasnovas; Miquel Adrover is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The formation of a heterogeneous set of advanced glycation end products (AGEs) is the final outcome of a non-enzymatic process that occurs in vivo on long-life biomolecules. This process, known as glycation, starts with the reaction between reducing sugars, or their autoxidation products, with the amino groups of proteins, DNA, or lipids, thus gaining relevance under hyperglycemic conditions. Once AGEs are formed, they might affect the biological function of the biomacromolecule and, therefore, induce the development of pathophysiological events. In fact, the accumulation of AGEs has been pointed as a triggering factor of obesity, diabetes-related diseases, coronary artery disease, neurological disorders, or chronic renal failure, among others. Given the deleterious consequences of glycation, evolution has designed endogenous mechanisms to undo glycation or to prevent it. In addition, many exogenous molecules have also emerged as powerful glycation inhibitors. This review aims to provide an overview on what glycation is. It starts by explaining the similarities and differences between glycation and glycosylation. Then, it describes in detail the molecular mechanism unde

Who reads An Overview on Glycation: Molecular Mechanisms, Impact on Proteins, Pathogenesis, and Inhibition?

Author

Ana Belén Uceda; Laura Mariño; Rodrigo Casasnovas; Miquel Adrover

Publisher

Springer Science and Business Media LLC

Published

2024

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)