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Monoclonal Antibody Therapy of Human Cancer (Developments in Oncology, 38) by Alton C. Morgan Jr., Robert W. Schroff (auth.), Kenneth A. Foon M.D., Alton C. Morgan Jr. PH.D. (eds.) is a nonfiction available to read on EtoBox.

What is Monoclonal Antibody Therapy of Human Cancer (Developments in Oncology, 38) about?

The major problems wi th the current modal i ties of cancer therapy are the lack of tumor specificity and the low therapeutic/toxic ratio of anticancer drugs and radiation therapy. A major advance in the treatment of cancer could be heralded by the development of a class of agents that have a greater degree of tumor specificity. The technique of hybridization of an immortal myeloma cell line with an antibody-producing B cell, developed by Kohler and Milstein (1), provides a technique by which monoclonal antibodies with considerable tumor specificity could be produced in unlimited quantities. Clinical trials evaluating the efficacy, toxicity, pharmacokinetics, and immunogenicity of murine antibodies in humans are currently underway. The use of animal tumor models is also very important in attempting to assess the use of monoclonal antibodies in vivo and, particularly, to assess immunoconjugates in cancer therapeutics. Unconjugated antibodies may be useful against cancer cells through the complement system or by cellmediated effector functions, but the use of antibody conjugated to drugs, toxins, or radioisotopes offers the greatest hope for the development of cancer-selective cytoto

Who reads Monoclonal Antibody Therapy of Human Cancer (Developments in Oncology, 38)?

Author

Alton C. Morgan Jr., Robert W. Schroff (auth.), Kenneth A. Foon M.D., Alton C. Morgan Jr. PH.D. (eds.)

Publisher

Springer US

Published

1985

Language

EN

ISBN

9781461296423

Category

nonfiction

Subjects

Medical, Medicine