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Can I read Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity on EtoBox?
Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity by Imadul Islam; Judi Bryant; Yuo-Ling Chou; Monica J. Kochanny; Wheeseong Lee; Gary B. Phillips; Hongyi Yu; Marc Adler; Marc Whitlow; Elena Ho; Dao Lentz; Mark A. Polokoff; Babu Subramanyam; James M. Wu; Daguang Zhu; Richard I. Feldman; Damian O. Arnaiz is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity about?
HTS screening identified 1 with micromolar inhibitory activity against PDK1. Optimization of 1 afforded 4i (BX-517) which has single-digit nanomolar activity against PDK1 and excellent selectivity against PKA.
Who reads Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Imadul Islam; Judi Bryant; Yuo-Ling Chou; Monica J. Kochanny; Wheeseong Lee; Gary B. Phillips; Hongyi Yu; Marc Adler; Marc Whitlow; Elena Ho; Dao Lentz; Mark A. Polokoff; Babu Subramanyam; James M. Wu; Daguang Zhu; Richard I. Feldman; Damian O. Arnaiz
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)