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The efficacy and adverse effects of PARP inhibitor combined with chemotherapy compared with chemotherapy alone in the treatment of cancer patient: A protocol for systematic review by Suyue Zhao; Tao Fang; Li Yao; Ying Zheng; Ling Zhang; Kexiang Zhu is a Medicine article available to read on EtoBox.

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## Background: There search of parp inhibitors has made great breakthroughs and progress. become a new type of medicine for cancer treatment,bringing hope to more advanced cancer patients.the purpose of this systematic review is to evaluate the clinical efficacy and adverse effects of parp inhibitorscombined with chemotherapy and chemotherapy alone in the treatment of cancer patients. ## Methods: We searched the following 4 databases, including: pubmed, embase, web of science, and cochrane library. the search will also be conducted at the clinical trial centers: clinicaltrials.gov, isrctn registry, who international clinical trials registration platform. the search date is as of september 22, 2020. there is no language restriction during this search, and the latest documents are kept updated through settings. the subject search terms were identified as "parp inhibitor", "neoplasms" and "dug therapy". the phase 2 and phase 3 clinical trials comparing parp inhibitor combined with chemotherapy and chemotherapy alone were included. the results include overall survival (os), progression-free survival (pfs), objective response rate (orr) and adverse events. two researchers separately com

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Author

Suyue Zhao; Tao Fang; Li Yao; Ying Zheng; Ling Zhang; Kexiang Zhu

Publisher

Lippincott Williams and Wilkins; Elsevier ; Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins; Elsevier BV; Lippincott Williams & Wilkins Ltd.; Medicine Publishing Company Ltd; Williams & Wilkins; Ovid Technologies (Wolters Kluwer Health) (ISSN 1357-3039)

Published

2020

Language

EN

Field

Medicine (Health Sciences)