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Molecular Design, Synthesis and Biological Activities of Amidines as New Ketol-acid Reductoisomerase Inhibitors by Bao Lei Wang; Yong Hong Li; Jian Guo Wang; Yi Ma; Zheng Ming Li is a Chemistry article available to read on EtoBox.

What is Molecular Design, Synthesis and Biological Activities of Amidines as New Ketol-acid Reductoisomerase Inhibitors about?

Diamidine (A) was identified in our in vitro bio-assay as a possible inhibitor of ketol-acid reductoisomerase (KARI) from the ACD database search based on the known three-dimensional crystal structure of KARI. An investigation on interaction of A on KARI active sites, led to the design and synthesis of 15 novel monoamidines. Some of those showed better biological activity than A on rice KARI (in vitro) and in greenhouse herbicidal tests (in vivo). The structure-biological activity relationship was investigated, which provides valuable information to further study of potential KARI inhibitors.

Who reads Molecular Design, Synthesis and Biological Activities of Amidines as New Ketol-acid Reductoisomerase Inhibitors?

Author

Bao Lei Wang; Yong Hong Li; Jian Guo Wang; Yi Ma; Zheng Ming Li

Publisher

Chinese Electronic Periodical Services; Elsevier ; Elsevier BV (ISSN 1001-8417)

Published

2008

Language

EN

Field

Chemistry (Physical Sciences)