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Can I read Prognostic Impact of the Immune-Cell Infiltrate in N1-Positive Non–Small-Cell Lung Cancer on EtoBox?
Prognostic Impact of the Immune-Cell Infiltrate in N1-Positive Non–Small-Cell Lung Cancer by Florian Eichhorn; Andreas Weigert; Rajender Nandigama; Laura V. Klotz; Jochen Wilhelm; Mark Kriegsmann; Michael Allgäuer; Thomas Muley; Petros Christopoulos; Rajkumar Savai; Martin E. Eichhorn; Hauke Winter is a Medicine article available to read on EtoBox.
What is Prognostic Impact of the Immune-Cell Infiltrate in N1-Positive Non–Small-Cell Lung Cancer about?
The analysis of peritumoral immune cells may help to identify patients that profit from further immunotherapy treatment after lung cancer surgery. We analyzed tumors from 174 patients and identified high levels of tumor infiltrating lymphocytes and M1-like tumor-associated macrophages as positive predictive factor whereas the abundance of regulatory T-cells was associated with poorer outcome in distinct histologic non-small-cell lung cancer subtypes. Introduction: The tumoral immune milieu plays a crucial role for the development of non-small-cell lung cancer (NSCLC) and may influence individual prognosis. We analyzed the predictive role of immune cell infiltrates after curative lung cancer surgery. Materials and Methods: The tumoral immune-cell infiltrate from 174 patients with pN1 NSCLC and adjuvant chemotherapy was characterized using immunofluorescence staining. The density and distribution of specific immune cells in tumor center (TU), invasive front (IF) and normal tissue (NORM) were correlated with clinical parameters and survival data. Results: Tumor specific survival (TSS) of all patients was 69.9% at 5 years. The density of tumor infiltrating lymphocytes (TIL) was higher
Who reads Prognostic Impact of the Immune-Cell Infiltrate in N1-Positive Non–Small-Cell Lung Cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Florian Eichhorn; Andreas Weigert; Rajender Nandigama; Laura V. Klotz; Jochen Wilhelm; Mark Kriegsmann; Michael Allgäuer; Thomas Muley; Petros Christopoulos; Rajkumar Savai; Martin E. Eichhorn; Hauke Winter
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)