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Synthesis, Characterization and Immunochemical Evaluation of Cephalosporin Antigenic Determinants by Francisco Sánchez-Sancho; Ezequiel Perez-Inestrosa; Rafael Suau; María I. Montañez; Cristobalina Mayorga; Maria J. Torres; Antonino Romano; Miguel Blanca is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Lack of knowledge of the exact chemical structure of cephalosporin antigenic determinants has hindered clinical interpretation of adverse reactions to these drugs and delayed understanding of the mechanisms involved in the specific recognition and binding of IgE molecules to these antigenic determinants. We further resolve the relationship between structure and activity of proposed antigenic chemicals, including the rational design and synthesis of these haptenic structures. Comparative RAST inhibition studies of the synthesized molecules revealed that they were recognized by IgE antibodies induced by cephalosporin antibiotics. Thus, these data indicate that recognition is mainly directed to the acyl side chain and to the β‐lactam fragment that remains linked to the carrier protein in the cephalosporin conjugation course. Copyright © 2003 John Wiley & Sons, Ltd.

Who reads Synthesis, Characterization and Immunochemical Evaluation of Cephalosporin Antigenic Determinants?

Author

Francisco Sánchez-Sancho; Ezequiel Perez-Inestrosa; Rafael Suau; María I. Montañez; Cristobalina Mayorga; Maria J. Torres; Antonino Romano; Miguel Blanca

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0952-3499)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)