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Expression of 5-HT Relates to Stem Cell Marker LGR5 in Patients with Gastritis and Gastric Cancer by Qian Niu; Lin Li; Caili Zhang; Changhai Qi; Qiufeng He; Yuanmin Zhu is a Medicine article available to read on EtoBox.
What is Expression of 5-HT Relates to Stem Cell Marker LGR5 in Patients with Gastritis and Gastric Cancer about?
## Background 5-Hydroxytryptamine (5-HT) and stem cells marker G-protein-coupled receptor 5 (LGR5) are associate with gastrointestinal inflammation and tumorigenesis. But the relationship between 5-HT and LGR5 is unclear. ## Objective To explore the expression and correlation of 5-HT and LGR5 in gastric mucosa of patients with gastritis and gastric cancer (GC). ## Methods A total of 41 patients with GC and 98 patients with chronic gastritis were included in this study. The expression of __TPH1__ mRNA, __LGR5__ mRNA and __β-catenin__ mRNA in gastric mucosa were explored by Real-time Quantitative polymerase chain reaction (qPCR). 5-HT-positive cells and LGR5-positive cells in gastric mucosa were detected by immunohistochemistry stains. The co-localization of 5-HT and chromogranin A (CgA), 5-HT receptor4 (5-HTR4) and LGR5 were detected by multiplex immunofluorescence. ## Results The expression of 5-HT and LGR5 in patients with GC was significantly higher than patients with chronic gastritis (__p__ < 0.05). The positive rate of 5-HT and LGR5 increased sequentially in the patients with non-atrophic gastritis, intestinal metaplasia and GC, which were 18.52%, 35.56% and 75.61% for 5-HT, a
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- Author
- Qian Niu; Lin Li; Caili Zhang; Changhai Qi; Qiufeng He; Yuanmin Zhu
- Publisher
- Springer US
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)