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c-Fos expression following context conditioning and deep brain stimulation in the bed nucleus of the stria terminalis in rats by Luyck, Kelly; Scheyltjens, Isabelle; Nuttin, Bart; Arckens, Lutgarde; Luyten, Laura is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is c-Fos expression following context conditioning and deep brain stimulation in the bed nucleus of the stria terminalis in rats about?
## Abstract Deep brain stimulation (DBS) in the bed nucleus of the stria terminalis (BST), a region implicated in the expression of anxiety, shows promise in psychiatric patients, but its effects throughout the limbic system are largely unknown. In male Wistar rats, we first evaluated the neural signature of contextual fear (N = 16) and next, of the anxiolytic effects of high-frequency electrical stimulation in the BST (N = 31), by means of c-Fos protein expression. In non-operated animals, we found that the left medial anterior BST displayed increased c-Fos expression in anxious (i.e., context-conditioned) versus control subjects. Moreover, control rats showed asymmetric expression in the basolateral amygdala (BLA) (i.e., higher intensities in the right hemisphere), which was absent in anxious animals. The predominant finding in rats receiving bilateral BST stimulation was a striking increase in c-Fos expression throughout much of the left hemisphere, which was not confined to the predefined regions of interest. To conclude, we found evidence for lateralized c-Fos expression during the expression of contextual fear and anxiolytic high-frequency electrical stimulation of the BST, p
Who reads c-Fos expression following context conditioning and deep brain stimulation in the bed nucleus of the stria terminalis in rats?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Luyck, Kelly; Scheyltjens, Isabelle; Nuttin, Bart; Arckens, Lutgarde; Luyten, Laura
- Publisher
- Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)